how to get pregnant with unexplained infertility

Unexplained Infertility? Explore your Options

Approximately 15-30% of couples experiencing infertility are diagnosed as having unexplained
infertility. This makes it one of the greatest causes of infertility. When infertile couples or
individuals have undergone all appropriate tests, and no cause for their infertility is
found, they are diagnosed with unexplained infertility. Unexplained infertility most likely
involves issues with poor egg or sperm quality or problems with the uterus or fallopian tubes
that aren’t identifiable during normal fertility testing.
The more likely causes of unexplained infertility involve:

1. Ovulation problems

2. Poor egg quality

3. Poor sperm quality

4. Insufficient frequency of sexual intercourse or intercourse not timed to coincide with

5. Problems with pelvic health, primarily with the fallopian tubes or uterus

Ovulatory disorders affect about 15% of all infertile couples and 40% of all infertile women,
says an article published by the National Center for Biotechnology Information. Many women
might ovulate normally but might still be unable to conceive. This unexplained infertility only
proves that there could be subtle issues with the ovulation process.
One study showed that for couples with unexplained infertility and over 3 years of trying
on their own, the cumulative pregnancy rate after 24 months of attempting conception
without any treatment was 28%. This number was found to be reduced by 10% for each
year that the female is over 31.

Treatment Options for Unexplained Infertility:

  1. Ovarian Stimulation / IUI:
    Intrauterine insemination (IUI) is often considered a first-line treatment for couples with unexplained or mild male-factor infertility because it is less invasive and less costly than IVF. IUI can be performed in a natural ovulatory cycle, or it can be combined with OS, which is intended to induce multiple follicular developments in an effort to improve the chances of pregnancy.
  2. Ovulation Induction
    When a woman fails to ovulate naturally, ovulation induction treatment is performed with the use of medication. The medication is prescribed at the beginning of a menstrual cycle to stimulate the ovaries to produce and develop eggs. Ovulation induction is done using the following drugs
    • Letrozole  
    • Clomiphene
    • Gonadotropins 
  1. IVF:
    Due to steady improvements in IVF technology over the past two decades, IVF has become the
    a most effective form of treatment for nearly all causes of infertility. For patients with
    unexplained infertility, OS-IUI with oral medications is generally considered first-line therapy,
    followed by IVF only if OS-IUI with oral medications is unsuccessful after several attempts.
    However, expedited treatment with IVF could reduce the emotional and physical burden to
    patients by shortening the overall time required to achieve pregnancy.
    The duration of infertility is important. The longer infertility, the less likely the couple is to
    conceive on their own. After 5 years of infertility, a couple with unexplained infertility has less
    then a 10% chance for success on their own. Furthermore, treatment decisions should be made in
    consideration of the significant unassisted pregnancy rate observed in couples with unexplained
    infertility and desired family size.
    Make sure you consult doctors from the Aaradhya Fertility Centre to be well informed about all
    the risks and complications involved before the process begins. It would also be great to stay
    under the supervision of the doctor after the treatment to cure complications on time. Call us at
    8886592229 or visit

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