Overview:
Semaglutide (trade name: Ozempic) is an approved drug to treat diabetes and for weight reduction. Semaglutide is a glucagon-like peptide (GLP-1R) analog.
Dosage and Duration:
It is used in doses from 0.5 mg to 1 mg (subcutaneously) once weekly for about 3–6 months, especially in cases of PCOS and for weight reduction.
Effects in PCOS:
In conditions like PCOS, it can help by reducing weight by about 6–11 kg, thus reducing BMI when used for around 3 months in overweight/obese patients.
It acts by:
Decreasing appetite
Increasing energy expenditure
Delaying gastric emptying
As a result:
It lowers cholesterol, triglycerides, and HDL levels
It reduces blood sugar and HbA1c levels over 6 weeks
Combination Therapy:
It can be accompanied by Tab. metformin and diet management for effective results. It helps in reducing insulin levels and insulin resistance in conditions like PCOD.
Mechanism Related to Reproductive Function:
Semaglutide is known to act on the brain, which further acts on GnRH pulses and on the pituitary gland, and further increases luteinizing (LH) hormone pulses. This helps in promoting ovulation.
Additional Effects:
Moreover, Semaglutide helps in reducing inflammation and fibrosis of the ovaries. It reduces blood sugar and HbA1c levels over 6 weeks when used continuously.
Conclusion:
Ultimately, it is a promising drug for weight reduction, especially in PCOS.
Precaution. Avoid pregnancy during the usage of semaglutide, as the effect of the drug on the fetus is not completely known.
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